Endocrine Abstracts

Objectives: Eversense XL is a fully implantable sensor for continuous glucose monitoring (CGM) that lasts for up to 180 days. Our objective was to perform a survey on user acceptance and satisfaction among our type 1 diabetic patients who had been using the Eversense XL CGM for at least 3 months.Methods: A questionnaire was devised in which the patients were asked about their experience with the Eversense XL CGM, including:-Compari...

Introduction: Recurrences of differenciated thyroid carcinoma are occasionally hard to locate; rhTSH-stimulated FDG PET-CT may offer a higher sensitivity, particularly when thyroglobulin in high, but its utility has not been clearly established. Methods: Review of the patient’s clinical record Results: A 61 years old woman noticed a right anterior neck lump when she was 47; FNAC was suggestive of a solid papillary thyroid carc...

Clinical Case: A hypertensive 60-year-old woman with nephroangiosclerotic stage IV chronic renal failure (eGFR 23.44 ml/min/1.73 m2) was referred to our hypertension clinic after the CT finding of a 26-mm left adrenal mass with adenoma density during hypertension workup, with normal right adrenal. Physical exam was unremarkable except for BP 167/98 mmHg. Plasma aldosterone was 353 ng/ml, PRA 1.3 ng/ml/h, ratio 90.2, K+3.1 mEq/l, and metanephrines were nor...

Introduction: The introduction of immunotherapy with checkpoint inhibitors for oncologic diseases has improved the survival and quality of life of our patients; however, these therapies are frequently associated with autoimmune endocrine disease.Methods: Revision of the patient’s clinical record and the related literature.Results: Clinical Case : An 88-year old woman was referred to our Endocrinology Clinic because of a PET i...

Introduction/aim: Neurological symptoms are rarely related to decompensated type 2 diabetes mellitus. However, thanks to complementary tests, we can identify this association more easily.Material and method: Review of the patient’s clinical record and the relevant literature.Results: A 76-year old man complained in the last year of a progressive, involuntary and disabling movement disorder consisting in hemichorea of the left...

Primary aldosteronism is now recognized as the most frequent cause of secondary hypertension, accounting for 5–10% of the total cases of hypertension. Reportedly it is associated with a risk of cardiovascular events above and beyond hypertension development. Notwithstanding its high prevalence and serious complications, it is widely infradiagnosed. Hereby we present the case of a normotensive 50-year old female patient who was diagnosed of probable left hypernephroma, but...

Introduction: Intracranial Idiopathic Hypertension (IIH) is a rare complication of testosterone therapy. It is usually benign, but may result and permanent blindness. Its diagnosis is based on a high CSF (> 25 cm H2O) pressure, in the absence of specific causes. The androgen receptor is expressed in the human choroid plexus, and may enhance the activity of Na+/K+-ATPase, and therefore CSF secretion.Methods: Review of the patient’s cli...

Introduction: The 48XXXY karyotype is an infrequent (incidence about 1/50000 male births) sporadic aneuploidy of the sex chromosomes, classically considered as a variant of the Klinefelter syndrome (47XXY). Although many of their characteristics are shared, patients with the 48XXXY karyotype suffer from additional endocrinological and neuropsychological disturbances which are not part of the classic Klinefelter syndrome. Hereby we present a clinical case.<p class="abstext"...

Introduction: During most of the autumn of 2022, the standard maintenance presentation of parenteral semaglutide (1.0 mg for weekly dosage) was temporarily unavailable. Many of the patients using this dose were switched to the standard maintenance dose of oral semaglutide (14 mg daily). The leaflet included with the product specifies that the 14 mg daily oral dose is equivalent to the 0.5 mg parenteral weekly dose, but this is most likely an interpolation, as there are no repo...

Introduction/Aim: New oral anticoagulant drugs such as the factor Xa inhibitor rivaroxaban are often preferred to the classic coumarins because they do not need frequent blood-test monitoring and have fever interactions with other drugs and foodstuffs. They are not, however, interaction free. Rivaroxaban is metabolized by oxidative degradation catalyzed by CYP3A4/5 and CYP2J2; it is also a substrate of the P-gp and ABCG2 efflux transporter proteins. CYP3A4 activity enhancers s...